Article
Sex and genetic associations with cerebrospinal fluid dopamine and metabolite production after severe traumatic brain injury.
Journal of neurosurgery - 1 Apr 2007
Wagner Amy K, Ren Dianxu, Conley Yvette P, Ma Xiecheng, Kerr Mary E, Zafonte Ross D, Puccio Ava M, Marion Donald W, Dixon C Edward
Abstract excerpt
OBJECT: Dopamine (DA) pathways have been implicated in cognitive deficits after traumatic brain injury (TBI). Both sex and the dopamine transporter (DAT) 3' variable number of tandem repeat polymorphism have been associated with differences in DAT protein density, and DAT protein affects both presynaptic DA release, through reverse transport, and DA reuptake. Catecholamines and associated metabolites are subject...
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