Rationale for, and approach to, studying modifiers of risk in persons with a genetic predisposition to colorectal cancer.

Abstract excerpt

We address the issue of modifiers of risk for persons who are, on average, at high risk of colorectal cancer due to carrying germline genetic mutations. We discuss how to estimate risk and assess modifiers using data from mutation-carrying families. A critical analytical issue is the adjustment for how families have been sampled (ascertainment). Only a few published studies have made appropriate adjustments and...

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