Article
TCF7L2 in the Go-DARTS study: evidence for a gene dose effect on both diabetes susceptibility and control of glucose levels.
Diabetologia - 1 Jun 2007
Kimber C H, Doney A S F, Pearson E R, McCarthy M I, Hattersley A T, Leese G P, Morris A D, Palmer C N A
Abstract excerpt
AIMS/HYPOTHESIS: The gene encoding transcription factor 7-like 2 (TCF7L2) has been identified as a type 2 diabetes locus from genome-wide linkage studies and subsequent association analysis. We investigated the role of two common variants in TCF7L2 in a large case-control study recruited from the Tayside region of Scotland, UK. SUBJECTS AND METHODS: We genotyped 6,516 participants for rs12255372 and rs7903146 and...
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