Article
Differential expression of molecular motors in the motor cortex of sporadic ALS.
Neurobiology of disease - 1 Jun 2007
Pantelidou Maria, Zographos Spyros E, Lederer Carsten W, Kyriakides Theodore, Pfaffl Michael W, Santama Niovi
Abstract excerpt
The molecular mechanisms underlying the selective neurodegeneration of motor neurons in amyotrophic lateral sclerosis (ALS) are inadequately understood. Recent breakthroughs have implicated impaired axonal transport, mediated by molecular motors, as a key element for disease onset and progression. The current work identifies the expression of 15 kinesin-like motors in healthy human motor cortex, including three...
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