Aseptic cure of pulmonary paracoccidioidomycosis can be achieved after a previous subcutaneous immunization of susceptible but not resistant mice.

doi:10.1016/j.micinf.2007.02.014

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Article

Aseptic cure of pulmonary paracoccidioidomycosis can be achieved after a previous subcutaneous immunization of susceptible but not resistant mice.

Microbes and infection - 1 May 2007

Arruda Celina, Vaz Celidéia A C, Calich Vera L G

Abstract excerpt

The murine model of paracoccidioidomycosis, the most important South American endemic mycosis, mimics the human disease: resistance is associated with preserved cellular immunity while T-cell anergy is related with susceptibility. In the present study we asked whether a previous s.c. infection which induces strong cellular immunity would protect mice against a lethal pulmonary challenge. It was found that...

Topics

Animals
Antibodies, Fungal
CD4-Positive T-Lymphocytes
CD8-Positive T-Lymphocytes
Disease Susceptibility
Fungal Vaccines
Genetic Predisposition to Disease
Hypersensitivity, Delayed
Immunization
Injections, Subcutaneous
Interferon-gamma
Interleukins
Lung
Lung Diseases, Fungal

Source

Open in PubMed

Identifiers

PMID: 17412629
DOI: 10.1016/j.micinf.2007.02.014

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Male

Mice

Paracoccidioides

Paracoccidioidomycosis