Article
Resistance to Paracoccidioides brasiliensis infection is linked to a preferential Th1 immune response, whereas susceptibility is associated with absence of IFN-gamma production.
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research - 1 Jan 2000
Kashino S S, Fazioli R A, Cafalli-Favati C, Meloni-Bruneri L H, Vaz C A, Burger E, Singer L M, Calich V L
Abstract excerpt
The secretion of interferon-gamma (IFN-gamma), interleukin-2 (IL-2), IL-4, IL-5, and IL-10 by antigen-stimulated lymph node cells, eosinophil maturation, and the antibody isotypes produced were examined during intraperitoneal infection of susceptible (B10.A) and resistant (A/Sn) mice with Paracoccidioides brasiliensis. Lymph node cells from resistant mice produced early and sustained levels of IFN-gamma and IL-2,...
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