Article
HIV type 1 subtype C gag and nef diversity in Southern Africa.
AIDS research and human retroviruses - 1 Mar 2007
Bredell Helba, Martin Darren P, Van Harmelen Joanne, Varsani Arvind, Sheppard Haynes W, Donovan Richard, Gray Clive M, Williamson Carolyn
Abstract excerpt
Several HIV-1 subtype C-specific gag- and/or nef-based vaccines are currently intended for clinical trial in southern Africa. Here we provide sequences of 64 gag and 45 nef genes sampled in Malawi, Zambia, Zimbabwe, and South Africa and assess the degree of southern African HIV-1 diversity that will confront these vaccines. Whereas reasonable phylogenetic evidence exists for geographical clustering of subtype C...
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