Article
The effect of gefitinib on B-RAF mutant non-small cell lung cancer and transfectants.
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2007
Toyooka Shinichi, Uchida Akiko, Shigematsu Hisayuki, Soh Junichi, Ogino Atsuko, Takata Minoru, Kiura Katsuyuki, Ouchida Mamoru, Kosaka Takayuki, Aoe Motoi, Mitsudomi Tetsuya, Date Hiroshi
Abstract excerpt
We previously reported one patient with squamous cell carcinoma of the lung that showed the long-term effect to gefitinib with complete response. In the present report, we examine the epidermal growth factor receptor (EGFR) and K-RAS, HER2, and B-RAF mutations in this patient to find a B-RAF exon...
Topics
- Blotting, Western
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- DNA Mutational Analysis
- ErbB Receptors
- Female
- Gefitinib
- Gene Expression Regulation, Neoplastic
- Genes, ras
- Humans
- Lung Neoplasms
- Male
- Middle Aged