Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Human MSH6 Deficiency Is Associated with Impaired Antibody Maturation

17 Jan 2012

Abstract excerpt

Ig class-switch recombination (Ig-CSR) deficiencies are rare primary immunodeficiencies characterized by defective switched isotype (IgG/IgA/IgE) production. Depending on the molecular defect, defective Ig-CSR may also be associated with impaired somatic hypermutation (SHM) of the Ig V regions. Although the mechanisms underlying Ig-CSR and SHM in humans have been revealed (at least in part) by studying natural...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic factors in colorectal cancer
Share to Immunodeficiency and Autoimmune Disorders
Share to T-cell and B-cell Immunology

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22250089
DOI: 10.4049/jimmunol.1102984

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Human MSH6 Deficiency Is Associated with Impaired Antibody MaturationPMID 22250089Read ↗

Immunoglobulin class-switch recombination deficienciesSemantic proximity Read ↗

Examination of Msh6- and Msh3-deficient Mice in Class Switching Reveals Overlapping and Distinct Roles of MutS Homologues in Antibody DiversificationSemantic proximity Read ↗

A Role for Msh6 But Not Msh3 in Somatic Hypermutation and Class Switch RecombinationSemantic proximity Read ↗

The mismatch repair protein Msh6 influences the in vivo AID targeting to the Ig locus.Semantic proximity Read ↗

Human PMS2 deficiency is associated with impaired immunoglobulin class switch recombinationSemantic proximity Read ↗

MSH2/MSH6 complex promotes error-free repair of AID-induced dU:G mispairs as well as error-prone hypermutation of A:T sites.Semantic proximity Read ↗

Role for Msh5 in the regulation of Ig class switch recombination.Semantic proximity Read ↗

A primary immunodeficiency characterized by defective immunoglobulin class switch recombination and impaired DNA repairSemantic proximity Read ↗

Somatic Hypermutation and Class Switch Recombination in Msh6−/−Ung−/− Double-Knockout MiceSemantic proximity Read ↗

Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.Semantic proximity Read ↗

Mismatch repair proteins and AID activity are required for the dominant negative function of C-terminally deleted AID in class switching.Semantic proximity Read ↗

No Overt Clinical Immunodeficiency Despite Immune Biological Abnormalities in Patients With Constitutional Mismatch Repair DeficiencySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.