Article
Role of differentially expressed microRNA-139-5p in the regulation of phenotypic internal anal sphincter smooth muscle tone.
Scientific reports - 3 May 2017
Singh Jagmohan, Mohanty Ipsita, Addya Sankar, Phillips Benjamin, Mee Yong Hwan, An Steven S, Penn Raymond B, Rattan Satish
Abstract excerpt
The present study focused on the role of microRNA-139-5p (miRNA-139-5p) in the regulation of basal tone in internal anal sphincter (IAS). Applying genome-wide miRNA microarrays on the phenotypically distinct smooth muscle cells (SMCs) within the rat anorectrum, we identified miRNA-139-5p as differentially expressed RNA repressor with highest expression in the purely phasic smooth muscle of anococcygeus (ASM) vs....
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