Article
[Analysis of loss of heterozygosity and microsatellite instability RAD52, RAD54 and RAD54B gene and BRCA1 gene mutation in breast cancer].
Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego - 1 Dec 2006
Romanowicz-Makowska Hanna, Smolarz Beata
Abstract excerpt
UNLABELLED: RAD51, RAD52, and RAD54 encode proteins that are critical to the repair of double-strand DNA breaks by homologous recombination. The objectives of this study were to determine the frequency of BRCA1 germ-line mutations and the RAD52, RAD54 and RAD54B microsatellite instability (MSI) and loss of heterozygosity (LOH) in patients with breast cancer. MATERIAL AND METHODS: Blood and tumour tissue were...
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