Article
Local genetic and environmental factors in asthma disease pathogenesis: chronicity and persistence mechanisms.
The European respiratory journal - 1 Apr 2007
Holgate S T, Davies D E, Powell R M, Howarth P H, Haitchi H M, Holloway J W
Abstract excerpt
While asthma is an inflammatory disorder of the airways usually associated with atopy, an important additional component is involvement of the epithelium and underlying mesenchyme acting as a trophic unit (EMTU). In addition to allergens, a wide range of environmental factors interact with the EMTU, such as virus infections, environmental tobacco smoke and pollutants, to initiate tissue damage and aberrant repair...
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