Article
Murine gammaherpesvirus 68 open reading frame 24 is required for late gene expression after DNA replication.
Journal of virology - 1 Jun 2007
Wong Elaine, Wu Ting-Ting, Reyes Nichole, Deng Hongyu, Sun Ren
Abstract excerpt
Open reading frame 24 (ORF24) of murine gammaherpesvirus 68 (MHV-68) is conserved among beta- and gammaherpesviruses; however, its function in viral replication has not been defined. Using MHV-68 as a model, we have identified ORF24 as being essential for viral replication. An ORF24-null virus was generated and shown to be defective in late gene expression. Expression of early genes, as well as viral genome...
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