Article
HIV-1 infection of human fetal thymocytes.
Journal of acquired immune deficiency syndromes - 1 Jan 1992
Tanaka K E, Hatch W C, Kress Y, Soeiro R, Calvelli T, Rashbaum W K, Rubinstein A, Lyman W D
Abstract excerpt
Some neonates with congenital human immunodeficiency virus type 1 (HIV-1) infection exhibit immune dysregulation. This suggests that fetal CD4+ cells, possibly thymocytes, may be infected during gestation. If thymocytes are infected, this may result in a disruption of T-cell differentiation. To e...
Topics
- Cells, Cultured
- DNA, Viral
- Female
- Flow Cytometry
- Gestational Age
- Giant Cells
- HIV-1
- Humans
- Immunohistochemistry
- Lymphocyte Activation
- Microscopy, Electron
- Phenotype
- Polymerase Chain Reaction
- Pregnancy
- T-Lymphocytes
- Thymus Gland
- Virion