Article
No association between Helicobacter pylori seropositivity and ornithine decarboxylase (ODC) A317G polymorphism, and no modification by NAD(P)H:qinone oxidoreductase 1 (NQO1) C609T.
Nagoya journal of medical science - 1 Jan 2007
Goto Yasuyuki, Nishio Kazuko, Ishida Yoshiko, Kawai Sayo, Osafune Tomo, Naito Mariko, Katsuda Nobuyuki, Hamajima Nobuyuki
Abstract excerpt
Our previous epidemiologic study reported that NAD(P)H:quinone oxidoreductase 1 (NQO1) 609C/C with full enzyme activity was a high risk genotype for Helicobacter pylori (H. pylori) seropositivity. Since NQO1 stabilizes ornithine decarboxylase (ODC), which attenuates the innate immune response through elevated polyamines, ODC functional polymorphisms may also influence H. pylori seropositivity. This study aimed to...
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