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Article

The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma.

Genetics in medicine : official journal of the American College of Medical Genetics - 1 Jun 2007

di Martino Erica, Hardie Laura J, Wild Christopher P, Gong Yun Y, Olliver Joanna R, Gough Martin D, Bird Nigel C

Abstract excerpt

PURPOSE: The role of genetic susceptibility to esophageal adenocarcinoma and its precursor lesion Barrett esophagus has not been fully elucidated. This study investigated the effect of polymorphisms in the manganese superoxide dismutase (MnSOD) and NAD(P)H:quinone oxidoreductase 1 (NQO1) genes in modulating the risk of developing Barrett esophagus or esophageal adenocarcinoma. METHODS: A total of 584 patients...

Topics

Adenocarcinoma
Adult
Aged
Aged, 80 and over
Barrett Esophagus
Esophageal Neoplasms
Esophagitis, Peptic
Female
Genetic Predisposition to Disease
Humans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Male

Middle Aged

NAD(P)H Dehydrogenase (Quinone)

Polymorphism, Single Nucleotide

Risk Factors

Source

Identifiers

PMID: 17575500
DOI: 10.1097/gim.0b013e3180654ccd

Genes

NQO1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-17575500-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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The NAD(P)H:quinone oxidoreductase I C609T polymorphism modifies the risk of Barrett esophagus and esophageal adenocarcinoma.PMID 17575500Read ↗

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