Article
Investigation of the human ANP gene in type 1 diabetic nephropathy: case-control and follow-up studies.
Diabetes - 1 May 2004
Roussel Ronan, Trégouët David-Alexandre, Hadjadj Samy, Jeunemaître Xavier, Marre Michel
Abstract excerpt
The atrial natriuretic peptide gene (PND) is a candidate gene for diabetic nephropathy. We systematically analyzed five nonsynonymous PND polymorphisms and tested the association of genotype and haplotype distributions with diabetic nephropathy in a cross-sectional study and a 6-year follow-up study (489 and 301 type 1 diabetic patients, respectively). For this purpose, a new maximum-likelihood method dealing...
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