Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA.

BMC biology - 21 Mar 2007

Baysal Bora E, Lawrence Elizabeth C, Ferrell Robert E

Abstract excerpt

BACKGROUND: Balancing selection operating for long evolutionary periods at a locus is characterized by the maintenance of distinct alleles because of a heterozygote or rare-allele advantage. The loci under balancing selection are distinguished by their unusually high polymorphism levels. In this report, we provide statistical and comparative genetic evidence suggesting that the SDHA gene is under long-term...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Electron Transport Complex II
Share to Pan troglodytes
Share to Protein Subunits

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Racial Groups

Share to Selection, Genetic

Share to Sequence Homology, Nucleic Acid

Share to Succinate Dehydrogenase

Share to Time Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 17376234
DOI: 10.1186/1741-7007-5-12
PMCID: PMC1852088

Genes

SDHA
SDHB
SDHC
SDHD

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 11 closest

Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA.PMID 17376234Read ↗

A recurrent stop-codon mutation in succinate dehydrogenase subunit B gene in normal peripheral blood and childhood T-cell acute leukemia.Semantic proximity Read ↗

Mitochondrial complex II and genomic imprinting in inheritance of paraganglioma tumors.Semantic proximity Read ↗

A human derived SSADH coding variant is replacing the ancestral allele shared with primates.Semantic proximity Read ↗

Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms.Semantic proximity Read ↗

Succinate dehydrogenase deficiency in human.Semantic proximity Read ↗

SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions.Semantic proximity Read ↗

High prevalence of founder mutations of the succinate dehydrogenase genes in the Netherlands.Semantic proximity Read ↗

A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability.Semantic proximity Read ↗

Mutations in SDHD lead to autosomal recessive encephalomyopathy and isolated mitochondrial complex II deficiency.Semantic proximity Read ↗

Molecular evolution of the human SRPX2 gene that causes brain disorders of the Rolandic and Sylvian speech areas.Semantic proximity Read ↗

Genomic imprinting at a boundary element flanking the SDHD locus.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.