Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A human derived SSADH coding variant is replacing the ancestral allele shared with primates.

Annals of human biology - 1 Jan 2000

Leone Ofelia, Blasi Paola, Palmerio Francesca, Kozlov Andrey I, Malaspina Patrizia, Novelletto Andrea

Abstract excerpt

BACKGROUND: A growing number of reports describe markers with high frequencies of the ancestral alleles in Africa, contrasting with high frequencies and possibly fixation of derived variants out of Africa. Such a pattern can be explained by either neutral or non-neutral processes. AIM: The study examined worldwide frequencies of two non-synonymous variants in NAD(+)-dependent succinic semialdehyde dehydrogenase...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to MCPH1 gene
Share to Genetics, Population

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genotype

Share to Polymorphism, Single Nucleotide

Share to Primates

Source

Identifiers

PMID: 17381057
DOI: 10.1080/03014460601035748

Genes

MCPH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A human derived SSADH coding variant is replacing the ancestral allele shared with primates.PMID 17381057Read ↗

SSADH variation in primates: intra- and interspecific data on a gene with a potential role in human cognitive functions.Semantic proximity Read ↗

Sequence variation in human succinate dehydrogenase genes: evidence for long-term balancing selection on SDHA.Semantic proximity Read ↗

Estimating the age of single nucleotide polymorphic sites in humans.Semantic proximity Read ↗

A functional polymorphism in the succinate-semialdehyde dehydrogenase (aldehyde dehydrogenase 5 family, member A1) gene is associated with cognitive ability.Semantic proximity Read ↗

Structure of human succinic semialdehyde dehydrogenase gene: identification of promoter region and alternatively processed isoforms.Semantic proximity Read ↗

Distortion in transmission of pathogenic SDHB- and SDHD-mutated alleles from parent to offspring.Semantic proximity Read ↗

Geographically separate increases in the frequency of the derived ADH1B*47His allele in eastern and western Asia.Semantic proximity Read ↗

Functional Characterization of a Spectrum of Genetic Variants in a Family With Succinic Semialdehyde Dehydrogenase DeficiencySemantic proximity Read ↗

Genetic variation in a compound short tandem repeat/Alu haplotype system at the SB19.3 locus: properties and interpretation.Semantic proximity Read ↗

Functional Characterization of a Spectrum of Genetic Variants in a Family with Succinic Semialdehyde Dehydrogenase Deficiency.Semantic proximity Read ↗

Adaptive evolution of ASPM, a major determinant of cerebral cortical size in humans.Semantic proximity Read ↗

mtDNA analysis in ancient Nubians supports the existence of gene flow between sub-Sahara and North Africa in the Nile Valley.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.