Article
Alanine to serine polymorphism at position 986 of the calcium-sensing receptor associated with coronary heart disease, myocardial infarction, all-cause, and cardiovascular mortality.
The Journal of clinical endocrinology and metabolism - 1 Jun 2007
März Winfried, Seelhorst Ursula, Wellnitz Britta, Tiran Beate, Obermayer-Pietsch Barbara, Renner Wilfried, Boehm Bernhard O, Ritz Eberhard, Hoffmann Michael M
Abstract excerpt
BACKGROUND: Disorders of calcium homeostasis have been implicated in atherosclerosis. The calcium-sensing receptor (CASR) is crucial to the regulation of calcium metabolism. An alanine (A) to serine (S) polymorphism at codon 986 (A986S) of the CASR gene has been associated with higher calcium and osteoporosis; the association with coronary artery disease (CAD) has not been studied. METHODS AND RESULTS: We...
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