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Article

Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor.

The Journal of clinical endocrinology and metabolism - 1 Nov 2004

Scillitani Alfredo, Guarnieri Vito, De Geronimo Simona, Muscarella Lucia Anna, Battista Claudia, D'Agruma Leonardo, Bertoldo Francesco, Florio Cinzia, Minisola Salvatore, Hendy Geoffrey N, Cole David E C

Abstract excerpt

Blood ionized calcium (iCa) is a quantitative trait subject to genetic influence. iCa is maintained in a narrow range through the action of the calcium-sensing receptor (CASR) controlling PTH secretion and calcium excretion. A CASR single nucleotide polymorphism (SNP) prevalent in Caucasian populations (A986S) has shown significant association with iCa in a cohort of young women, but association with the...

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Source

Identifiers

PMID: 15531522
DOI: 10.1210/jc.2004-0129

Genes

CASR
PTH

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Blood ionized calcium is associated with clustered polymorphisms in the carboxyl-terminal tail of the calcium-sensing receptor.PMID 15531522Read ↗

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A986S polymorphism of the calcium-sensing receptor and circulating calcium concentrations.Semantic proximity Read ↗

Genetic variation at the calcium-sensing receptor (CASR) locus: implications for clinical molecular diagnostics.Semantic proximity Read ↗

Calcium Sensing Receptor Common Variants Influence the Effects of Serum Calcium on Coronary Artery Disease RisksSemantic proximity Read ↗

The role of the calcium-sensing receptor in disorders of abnormal calcium handling and cardiovascular disease.Semantic proximity Read ↗

Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene.Semantic proximity Read ↗

Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.Semantic proximity Read ↗

Polymorphisms Contributing to Calcium Status: A Systematic Review.Semantic proximity Read ↗

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Calcium-sensing receptor gene polymorphism A986S does not predict serum calcium level, bone mineral density, calcaneal ultrasound indices, or fracture rate in a large cohort of elderly women.Semantic proximity Read ↗

SINGLE-NUCLEOTIDE POLYMORPHISMS OF CALCIUM-SENSING RECEPTOR ENCODING GENE ASSOCIATED WITH CALCIUM KIDNEY STONE DISEASE IN BABYLON PROVINCESemantic proximity Read ↗

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