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Article

Two synergistic activation mechanisms of alpha2beta1 integrin-mediated collagen binding.

The Journal of biological chemistry - 11 May 2007

Connors Wendy L, Jokinen Johanna, White Daniel J, Puranen J Santeri, Kankaanpää Pasi, Upla Paula, Tulla Mira, Johnson Mark S, Heino Jyrki

Abstract excerpt

Activation of protein kinase C by 12-O-tetradecanoylphorbol-13-acetate (TPA) induces ligand-independent aggregation of a cell surface collagen receptor, alpha2beta1 integrin. Concomitantly, TPA increases the avidity of alpha2beta1 for collagen and the number of conformationally activated alpha2beta1 integrins. The structural change was shown using a monoclonal antibody 12F1 that recognizes the "open" (active)...

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PMID: 17374611
DOI: 10.1074/jbc.M700759200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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