Article
Vaccination of calves with EspA, a key colonisation factor of Escherichia coli O157:H7, induces antigen-specific humoral responses but does not confer protection against intestinal colonisation.
Veterinary microbiology - 20 Jul 2007
Dziva Francis, Vlisidou Isabella, Crepin Valérie F, Wallis Timothy S, Frankel Gad, Stevens Mark P
Abstract excerpt
Enterohaemorrhagic Escherichia coli (EHEC) infections in humans are frequently associated with direct or indirect contact with ruminant faeces and may result in haemorrhagic colitis and severe renal and neurological sequelae. Broadly cross-protective vaccines for control of EHEC do not yet exist and the molecular mechanisms that influence bacterial persistence in the intestines of ruminants are incompletely...
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