Article
Effect of Val92Met and Arg163Gln variants of the MC1R gene on freckles and solar lentigines in Japanese.
Pigment cell research - 1 Apr 2007
Motokawa Tomonori, Kato Tomomi, Hashimoto Yuki, Katagiri Takayuki
Abstract excerpt
Melanocortin-1 receptor (MC1R) is a highly polymorphic gene. The variety of the variants is dependent on the ethnic background of the individual. In Caucasians, specific variants, such as Arg151Cys, Arg160Trp, and Asp294His, are strongly associated with red hair, skin cancer and pigmented lesions. In Asians, there is no report so far indicating an association such as that observed in Caucasians. Here, we...
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