Article

Combating oncogene activation associated with retrovirus-mediated gene therapy of X-linked severe combined immunodeficiency

2007-05-01

Abstract excerpt

A successful gene therapy clinical trial that also encountered serious adverse effects has sparked extensive study and debate about the future directions for retrovirus-mediated interventions. Treatment of X-linked severe combined immunodeficiency with an oncoretrovirus harboring a normal copy of the gc gene was applied in two clinical trials, essentially curing 13 of 16 infants, restoring a normal immune system w...

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Identifiers and source

Literature Corpus work: 93e06add-5e92-57e9-80bc-178375fb769b
DOI: 10.1590/s0100-879x2006005000085

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