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Article

<i>COPS3</i> amplification and clinical outcome in osteosarcoma

15 Mar 2007

Abstract excerpt

BACKGROUND: Amplification of several genes that map to a region of chromosome 17p11.2, including COPS3, was observed in high-grade osteosarcoma. These genes were also shown to be overexpressed and may be involved in osteosarcoma tumorigenesis. COPS3 encodes a subunit of the COP9 signalosome implicated in the ubiquitination and ultimately degradation of the P53 tumor suppressor. To determine the relation between...

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PMID: 17366602
DOI: 10.1002/cncr.22595

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