Article
Molecular characterization of beta-thalassemia in Egyptians.
Human mutation - 1 Jan 1993
Hussein I R, Temtamy S A, el-Beshlawy A, Fearon C, Shalaby Z, Vassilopoulos G, Kazazian H H
Abstract excerpt
We sought to determine the spectrum of mutations producing beta-thalassemia in Egypt using genomic PCR and a variety of mutation-screening procedures. Thirty-four beta-thalassemia and three Hb S/beta-thalassemia patients originating from different regions of Egypt were studied, and the causative mutation was found in 69 of 71 (97%) beta-thalassemia genes. Four mutations accounted for 78% of beta-thalassemia genes...
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