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Article

DNA methylation enables transposable element-driven genome expansion.

Proceedings of the National Academy of Sciences of the United States of America - 11 Aug 2020

Zhou Wanding, Liang Gangning, Molloy Peter L, Jones Peter A

Abstract excerpt

Multicellular eukaryotic genomes show enormous differences in size. A substantial part of this variation is due to the presence of transposable elements (TEs). They contribute significantly to a cell's mass of DNA and have the potential to become involved in host gene control. We argue that the suppression of their activities by methylation of the C-phosphate-G (CpG) dinucleotide in DNA is essential for their...

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Identifiers

PMID: 32719115
DOI: 10.1073/pnas.1921719117
PMCID: PMC7431005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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