Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impaired angiogenesis in aminopeptidase N-null mice.

Proceedings of the National Academy of Sciences of the United States of America - 13 Mar 2007

Rangel Roberto, Sun Yan, Guzman-Rojas Liliana, Ozawa Michael G, Sun Jessica, Giordano Ricardo J, Van Pelt Carolyn S, Tinkey Peggy T, Behringer Richard R, Sidman Richard L, Arap Wadih, Pasqualini Renata

Abstract excerpt

Aminopeptidase N (APN, CD13; EC 3.4.11.2) is a transmembrane metalloprotease with several functions, depending on the cell type and tissue environment. In tumor vasculature, APN is overexpressed in the endothelium and promotes angiogenesis. However, there have been no reports of in vivo inactivat...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to CD13 Antigens
Share to Exons
Share to Gene Expression Regulation, Enzymologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Knockout

Share to Mice, Transgenic

Share to Models, Genetic

Share to Neovascularization, Physiologic

Share to Retinal Degeneration

Source

Open in PubMed Open full text

Identifiers

PMID: 17360568
DOI: 10.1073/pnas.0611653104
PMCID: PMC1815469

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17360568-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impaired angiogenesis in aminopeptidase N-null mice.PMID 17360568Read ↗

CD13/APN is activated by angiogenic signals and is essential for capillary tube formationSemantic proximity Read ↗

Neprilysin inhibits angiogenesis via proteolysis of fibroblast growth factor-2.Semantic proximity Read ↗

Characterization of oxygen-induced retinopathy in mice carrying an inactivating point mutation in the catalytic site of ADAM15.Semantic proximity Read ↗

Retardation of retinal vascular development in apelin-deficient mice.Semantic proximity Read ↗

Neuropilin 1 (NRP1) hypomorphism combined with defective VEGF-A binding reveals novel roles for NRP1 in developmental and pathological angiogenesisSemantic proximity Read ↗

The Role of the Ectopeptidase APN/CD13 in CancerSemantic proximity Read ↗

Targeting of both mouse neuropilin-1 and neuropilin-2 genes severely impairs developmental yolk sac and embryonic angiogenesis.Semantic proximity Read ↗

Neuropilins: structure, function and role in diseaseSemantic proximity Read ↗

ADAM9 Is Involved in Pathological Retinal NeovascularizationSemantic proximity Read ↗

Prostate specific membrane antigen (PSMA) regulates angiogenesis independently of VEGF during ocular neovascularization.Semantic proximity Read ↗

Vascular abnormalities and elevated blood pressure in mice lacking adrenomedullin gene.Semantic proximity Read ↗

AIBP Limits Angiogenesis Through γ-Secretase-Mediated Upregulation of Notch SignalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.