Article
Dynamic balance of multiple myeloma clonogenic side population cell percentages controlled by environmental conditions.
International journal of cancer - 1 Mar 2015
Wen Jianguo, Tao Wenjing, Kuiatse Isere, Lin Pei, Feng Yongdong, Jones Richard J, Orlowski Robert Z, Zu Youli
Abstract excerpt
Cancer stem cells are key drivers of tumor progression and disease recurrence in multiple myeloma (MM). However, little is known about the regulation of MM stem cells. Here, we show that a population of MM cells, known as the side population (SP), exhibits stem-like properties. Cells that constitute the SP in primary MM isolates are negative or seldom expressed for CD138 and CD20 markers. In addition, the SP...
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