Article
Screening assays for heart function mutants in Drosophila.
BioTechniques - 1 Jul 2004
Wessells Robert J, Bodmer Rolf
Abstract excerpt
The rapid life cycle and genetic tractability of Drosophila make it an ideal organism for large-scale genetic screens. Here we describe a novel assay for pupal heart rate and rhythmicity as well as techniques to measure adult cardiac stress response. These assays can be powerfully combined to concurrently screen for both mutations affecting cardiac function and mutations affecting the age-dependent decline in...
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