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Article

A Drosophila model of spinal muscular atrophy uncouples snRNP biogenesis functions of survival motor neuron from locomotion and viability defects.

Cell reports - 28 Jun 2012

Praveen Kavita, Wen Ying, Matera A Gregory

Abstract excerpt

The spinal muscular atrophy (SMA) protein, survival motor neuron (SMN), functions in the biogenesis of small nuclear ribonucleoproteins (snRNPs). SMN has also been implicated in tissue-specific functions; however, it remains unclear which of these is important for the etiology of SMA. Smn null mutants display larval lethality and show significant locomotion defects as well as reductions in minor-class...

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Share to Animals, Genetically Modified
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Muscular Atrophy, Spinal

Share to Protein Structure, Quaternary

Share to Ribonucleoproteins, Small Nuclear

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Source

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Identifiers

PMID: 22813737
DOI: 10.1016/j.celrep.2012.05.014
PMCID: PMC3405901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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