Article
Adipose tissue expression of the glycerol channel aquaporin-7 gene is altered in severe obesity but not in type 2 diabetes.
The Journal of clinical endocrinology and metabolism - 1 Sept 2007
Ceperuelo-Mallafré V, Miranda M, Chacón M R, Vilarrasa N, Megia A, Gutiérrez C, Fernández-Real J M, Gómez J M, Caubet E, Frühbeck G, Vendrell J
Abstract excerpt
CONTEXT: Aquaporin-7 is required for efflux of glycerol from adipocytes and influences whole-body glucose homeostasis in animal studies. OBJECTIVE: Our objective was to test the hypothesis that AQP7 gene expression levels may be affected by presence of obesity and type 2 diabetes in humans. DESIGN: The obesity study cohort consisted of 12 lean, 22 nonseverely obese, and 13 severely obese subjects. The type 2...
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