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Article

Hypoxic preconditioning protects human brain endothelium from ischemic apoptosis by Akt-dependent survivin activation.

American journal of physiology. Heart and circulatory physiology - 1 Jun 2007

Zhang Yunhong, Park Tae S, Gidday Jeffrey M

Abstract excerpt

Preconditioning-induced ischemic tolerance is well documented in the brain, but cell-specific responses and mechanisms require further elucidation. The aim of this study was to develop an in vitro model of ischemic tolerance in human brain microvascular endothelial cells (HBMECs) and to examine the roles of phosphatidylinositol 3-kinase (PI3-kinase)/Akt and the inhibitor-of- apoptosis protein, survivin, in the...

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Source

Identifiers

PMID: 17337592
DOI: 10.1152/ajpheart.01098.2006

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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