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Article

Detection of catechol-O-methyltransferase Val158Met polymorphism by a simple one-step tetra-primer amplification refractory mutation system-PCR.

Molecular and cellular probes - 1 Jun 2007

Ruiz-Sanz José Ignacio, Aurrekoetxea Igor, Ruiz del Agua Ainhoa, Ruiz-Larrea María Begoña

Abstract excerpt

The G-->A transition at nucleotide 21881 of the human catechol-O-methyltransferase (COMT) gene represents a functional genetic polymorphism (Val158Met), rendering an enzyme with reduced activity that has been associated with psychiatric disorders and estrogen-related cancers. A new method for the detection of this polymorphism is described, based on the tetra-primer amplification refractory mutation...

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Source

Identifiers

PMID: 17337160
DOI: 10.1016/j.mcp.2006.12.001

Genes

COMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Detection of catechol-O-methyltransferase Val158Met polymorphism by a simple one-step tetra-primer amplification refractory mutation system-PCR.PMID 17337160Read ↗

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