Article
A type 1 diabetes subgroup with a female bias is characterised by failure in tolerance to thyroid peroxidase at an early age and a strong association with the cytotoxic T-lymphocyte-associated antigen-4 gene.
Diabetologia - 1 Apr 2007
Howson J M M, Dunger D B, Nutland S, Stevens H, Wicker L S, Todd J A
Abstract excerpt
AIMS/HYPOTHESIS: HLA haplotypes DRB1*03_DQB1*02 and DRB1*04_DQB1*0302, and allelic variation of the T cell regulatory gene cytotoxic T-lymphocyte-associated antigen-4 (CTLA4) and of the T cell activation gene protein tyrosine phosphatase, non-receptor type 22 (lymphoid) (PTPN22) have been associated with type 1 diabetes and autoimmune thyroid disease. Using thyroid peroxidase autoantibodies (TPOAbs) as an...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.