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Article

Mutations in APP have independent effects on Abeta and CTFgamma generation.

Neurobiology of disease - 1 Nov 2004

Hecimovic Silva, Wang Jun, Dolios Georgia, Martinez Maribel, Wang Rong, Goate Alison M

Abstract excerpt

Understanding the molecular mechanism of beta-amyloid (Abeta) generation is crucial for Alzheimer's disease pathogenesis as well as for normal APP function. The transmembrane domain (TM) of APP appears to undergo presenilin-dependent gamma-secretase cleavage at two topologically distinct sites: a site in the middle of the TM domain that is crucial for the generation of Abeta-peptides, and a site close to the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 15474359
DOI: 10.1016/j.nbd.2004.04.018

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Mutations in APP have independent effects on Abeta and CTFgamma generation.PMID 15474359Read ↗

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