Article
GCF2: expression and molecular analysis of repression.
Biochimica et biophysica acta - 1 Oct 2003
Rikiyama Toshiki, Curtis Joseph, Oikawa Masaya, Zimonjic Drazen B, Popescu Nicholas, Murphy Barbara A, Wilson Melissa A, Johnson Alfred C
Abstract excerpt
GC-binding factor 2 (GCF2) is a transcriptional repressor that decreases activity of the epidermal growth factor receptor (EGFR) and other genes. We have mapped the gene for GCF2 by fluorescence in situ hybridization (FISH) to chromosome 2q37. Sequence analysis of the GCF2 gene and cDNA showed that the gene consists of eight exons and introns and spans 73 kbp of DNA. Northern blot analysis showed that GCF2 mRNA...
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