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Article

Absence of mechanical loading in utero influences bone mass and architecture but not innervation in Myod-Myf5-deficient mice.

Journal of anatomy - 1 Mar 2007

Gomez Cédric, David Valentin, Peet Nicola M, Vico Laurence, Chenu Chantal, Malaval Luc, Skerry Timothy M

Abstract excerpt

Although the responses of bone to increased loading or exercise have been studied in detail, our understanding of the effects of decreased usage of the skeleton has been limited by the scarcity of suitable models. Such models should ideally not affect bone innervation, which appears to be a mediator of physiological responses of bone to unloading. MyoD-/-/Myf5-/- (dd/ff) mice lack skeletal muscle, so the fetuses...

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Source

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Identifiers

PMID: 17331176
DOI: 10.1111/j.1469-7580.2007.00698.x
PMCID: PMC2100282

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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