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Article

Family history of diabetes links impaired substrate switching and reduced mitochondrial content in skeletal muscle.

Diabetes - 1 Mar 2007

Ukropcova Barbara, Sereda Olga, de Jonge Lilian, Bogacka Iwona, Nguyen Tuong, Xie Hui, Bray George A, Smith Steven R

Abstract excerpt

Insulin resistance is associated with metabolic inflexibility, impaired switching of substrate oxidation from fatty acids to glucose in response to insulin. Impaired switching to fat oxidation in response to a high-fat diet (HFD) is hypothesized to contribute to insulin resistance. The objective of this study was to test the hypothesis that defects in substrate switching in response to insulin and a HFD are...

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Share to Body Composition
Share to Diabetes Mellitus, Type 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Mitochondria, Muscle

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Source

Identifiers

PMID: 17327442
DOI: 10.2337/db06-0521

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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