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Article

Dynamic changes in fat oxidation in human primary myocytes mirror metabolic characteristics of the donor.

The Journal of clinical investigation - 1 Jul 2005

Ukropcova Barbara, McNeil Michele, Sereda Olga, de Jonge Lilian, Xie Hui, Bray George A, Smith Steven R

Abstract excerpt

Metabolic flexibility of skeletal muscle, that is, the preference for fat oxidation (FOx) during fasting and for carbohydrate oxidation in response to insulin, is decreased during insulin resistance. The aim of this study was to test the hypothesis that the capacity of myotubes to oxidize fat in vitro reflects the donor's metabolic characteristics. Insulin sensitivity (IS) and metabolic flexibility of 16 healthy,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 16007256
DOI: 10.1172/JCI24332
PMCID: PMC1159139

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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