Article
Effects of Distal Mutations on Prolyl-Adenylate Formation of Escherichia coli Prolyl-tRNA Synthetase.
The protein journal - 1 Oct 2020
Zajac Jonathan, Anderson Heidi, Adams Lauren, Wangmo Dechen, Suhail Shanzay, Almen Aimee, Berns Lauren, Coerber Breanna, Dawson Logan, Hunger Andrea, Jehn Julia, Johnson Joseph, Plack Naomi, Strasser Steven, Williams Murphi, Bhattacharyya Sudeep, Hati Sanchita
Abstract excerpt
Enzymes play important roles in many biological processes. Amino acid residues in the active site pocket of an enzyme, which are in direct contact with the substrate(s), are generally believed to be critical for substrate recognition and catalysis. Identifying and understanding how these "catalytic" residues help enzymes achieve enormous rate enhancement has been the focus of many structural and biochemical...
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