Article
Immunohistochemical study of p53 and angiogenesis in benign and preneoplastic oral lesions and oral squamous cell carcinoma.
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics - 1 Mar 2007
Abbas Naglaa Fathy, Labib El-Sharkawy Sonia, Abbas Effat Ahmed, Abdel Monem El-Shaer Marwa
Abstract excerpt
OBJECTIVES: Mutation of the p53 gene and overexpression of its protein are frequent in human cancer, suggesting that these events play a critical role in the onset or progression of many types of tumors. Angiogenesis also has been demonstrated to be associated with tumor progression, aggressiveness, and metastases. This study aimed to investigate-in normal oral epithelium, hyperplasia, dysplasia, and invasive...
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