Article
The post-translational phenotype of collagen synthesized by SAOS-2 osteosarcoma cells.
Bone - 1 May 2007
Fernandes Russell J, Harkey Michael A, Weis Maryann, Askew Jennifer W, Eyre David R
Abstract excerpt
The human osteosarcoma-derived cell line, SAOS-2, exhibits many of the phenotypic characteristics of osteoblasts including the deposition of types I and V collagens in an extracellular matrix. Lesser amounts of collagen XI chains were also detected. The cell layer collagen contains hydroxylysyl pyridinoline cross-links but without the accompanying lysyl pyridinoline typical of human bone collagen. This indicates...
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