Article
Hydroxylation of collagen type I: evidence that both lysyl and prolyl residues are overhydroxylated in osteogenesis imperfecta.
European journal of clinical investigation - 1 May 1995
Lehmann H W, Rimek D, Bodo M, Brenner R E, Vetter U, Wörsdörfer O, Karbowski A, Müller P K
Abstract excerpt
The composition of the collagens secreted into the media of fibroblast cultures of 39 patients with osteogenesis imperfecta (OI) was the same in controls and OI cultures. An abnormal migration pattern of collagens upon SDS-PAGE was evident in one third of the cultures investigated. Lysyl and prol...
Topics
- Adolescent
- Adult
- Body Height
- Cells, Cultured
- Child
- Child, Preschool
- Collagen
- Female
- Fibroblasts
- Fractures, Bone
- Humans
- Hydroxylation
- Hydroxylysine
- Hydroxyproline
- Infant
- Lysine
- Male
- Middle Aged