The biological functions of the methyl-CpG-binding protein MeCP2 and its implication in Rett syndrome.

doi:10.1016/s0387-7604(01)00333-3

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Article

The biological functions of the methyl-CpG-binding protein MeCP2 and its implication in Rett syndrome.

Brain & development - 1 Dec 2001

Nan X, Bird A

Abstract excerpt

Methylation of DNA is essential for development in the mouse and plays an important role in inactivation of the X-chromosome, genomic imprinting and gene silencing. The properties of the methyl-CpG binding proteins (MeCPs) are being proved to be the key to interpreting the connection between DNA methylation and transcriptional repression. The founder member of the family, MeCP2, consists of a single polypeptide...

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PMID: 11738839
DOI: 10.1016/s0387-7604(01)00333-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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