Monitoring gene changes during antiepileptic drug therapy to widen the safety window and reduce pharmacoresistance.

Abstract excerpt

A novel and potentially effective way to decrease pharmacoresistance is to widen an antiepileptic drug's (AED) safety window by altering its efficacy-toxicity relationship to reduce the frequency or eliminate the occurrence of drug-induced toxicities. The first step in this process is to identify specific AED toxicities that are common, objective, reliable to assess, and exhibit both interpatient and interdrug...

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