Article
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
PloS one - 21 Feb 2007
Ugurel Selma, Thirumaran Ranjit K, Bloethner Sandra, Gast Andreas, Sucker Antje, Mueller-Berghaus Jan, Rittgen Werner, Hemminki Kari, Becker Jürgen C, Kumar Rajiv, Schadendorf Dirk
Abstract excerpt
In melanoma, the RAS/RAF/MEK/ERK signalling pathway is an area of great interest, because it regulates tumor cell proliferation and survival. A varying mutation rate has been reported for B-RAF and N-RAS, which has been largely attributed to the differential source of tumor DNA analyzed, e.g., fixed tumor tissues or in vitro propagated melanoma cells. Notably, this variation also interfered with interpreting the...
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