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Article

Degradation strategy of cyclin D1 in cancer cells and the potential clinical application

18 Aug 2022

Abstract excerpt

Cyclin D1 has been reported to be upregulated in several solid and hematologic tumors, promoting cancer progression. Thus, decreasing cyclin D1 by degradation could be a promising target strategy for cancer therapy. This mini review summarizes the roles of cyclin D1 in tumorigenesis and progression and its degradation strategies. Besides, we proposed an exploration of the degradation of cyclin D1 by FBX4, an F...

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PMID: 36059670
DOI: 10.3389/fonc.2022.949688

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