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Antigenic evolution of H3N2 influenza A viruses in swine in the United States from 2012 to 2016

16 Sept 2018

Abstract excerpt

BACKGROUND: Six amino acid positions (145, 155, 156, 158, 159, and 189, referred to as the antigenic motif; H3 numbering) in the globular head region of hemagglutinin (HA1 domain) play an important role in defining the antigenic phenotype of swine Clade IV (C-IV) H3N2 IAV, containing an H3 from a late 1990s human-to-swine introduction. We hypothesized that antigenicity of a swine C-IV H3 virus could be inferred...

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PMID: 30216671
DOI: 10.1111/irv.12610

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